Postdoc (m/f/x) in development of electron microscopy methods for elemental mapping in cryopreserved macromolecular complexes
About the Institute
The Max Planck Institute of Biophysics is a leading international research institute that uses and develops biophysical, biochemical and computational methods to investigate the structure, dynamics and function of cellular systems at the molecular scale. It consists of about 200 employees from more than 25 countries, and is located at the Campus Riedberg in Frankfurt am Main.
About the position
A postdoctoral position is available in the group of Dr. Bonnie Murphy at the Max Planck Institute of Biophysics in Frankfurt, Germany to work within the ERC-funded project ‘REEL-EM’. The project aims to develop techniques for elemental mapping within cryo-preserved macromolecular complexes. The approach brings together the methods of analytical electron microscopy with the powerful image processing tools of single-particle analysis, allowing these traditionally high-dose techniques to be applied to dose-sensitive biological samples. Proof-of-principle data (see O. Pfeil-Gardiner et al., BioRxiv 2024; DOI: https://doi.org/10.1101/2024.01.18.575858) show that our approach can generate elemental maps of more abundant elements within cryo-preserved macromolecular complexes, imaged at doses below 100 e-/Å2. The candidate will join a team working together to advance the sensitivity and resolution of the technique and to implement and improve workflows for efficient image acquisition and processing.
The Max Planck Institute of Biophysics is a leading international research institute that uses and develops biophysical, biochemical and computational methods to investigate the structure, dynamics and function of cellular systems at the molecular scale. It consists of about 200 employees from more than 25 countries, and is located at the Campus Riedberg in Frankfurt am Main.
About the position
A postdoctoral position is available in the group of Dr. Bonnie Murphy at the Max Planck Institute of Biophysics in Frankfurt, Germany to work within the ERC-funded project ‘REEL-EM’. The project aims to develop techniques for elemental mapping within cryo-preserved macromolecular complexes. The approach brings together the methods of analytical electron microscopy with the powerful image processing tools of single-particle analysis, allowing these traditionally high-dose techniques to be applied to dose-sensitive biological samples. Proof-of-principle data (see O. Pfeil-Gardiner et al., BioRxiv 2024; DOI: https://doi.org/10.1101/2024.01.18.575858) show that our approach can generate elemental maps of more abundant elements within cryo-preserved macromolecular complexes, imaged at doses below 100 e-/Å2. The candidate will join a team working together to advance the sensitivity and resolution of the technique and to implement and improve workflows for efficient image acquisition and processing.
Your qualification
An ideal candidate for the post will have demonstrated an enthusiasm for methods development in structural biology. A background in physics, biophysics, or materials science EM would be advantageous. Experience in electron microscopy, image processing and scientific programming will be key assets. A demonstrated interest in methods development and/or extensive experience in STEM-(EELS) and/or development work with hybrid pixel detectors would be additional assets.
We are looking for someone who is excited to work at the interface between fields. The candidate should have the ability to work independently but also enjoy collaboration and teamwork. For candidates with extensive experience, an appointment as senior scientist may be considered.
An ideal candidate for the post will have demonstrated an enthusiasm for methods development in structural biology. A background in physics, biophysics, or materials science EM would be advantageous. Experience in electron microscopy, image processing and scientific programming will be key assets. A demonstrated interest in methods development and/or extensive experience in STEM-(EELS) and/or development work with hybrid pixel detectors would be additional assets.
We are looking for someone who is excited to work at the interface between fields. The candidate should have the ability to work independently but also enjoy collaboration and teamwork. For candidates with extensive experience, an appointment as senior scientist may be considered.
Our offer
The Max Planck Institute of Biophysics in Frankfurt is an excellent place to apply and develop techniques in electron microscopy for understanding life from the cellular to the atomic scale. The institute offers a collegial environment, with many departments and research groups using advanced EM techniques for their work. Our central electron microscopy facility offers unparalleled instrument access for both high-resolution data collection and development work.
The salary for appointment at the level of postdoc is in accordance to the Public Sector Collective Agreement Bund (TVöD E14). The position is available immediately.
We also offer places for children aged 4 months and over in our daycare center within walking distance to the institute.
Applications from candidates with international experience are very welcome. The working language within the group is English.
The Max Planck Society strives for gender equality and diversity. We are also committed to increasing the number of individuals with disabilities in our workforce. Therefore, applicants of all backgrounds and identities are welcome.
The salary for appointment at the level of postdoc is in accordance to the Public Sector Collective Agreement Bund (TVöD E14). The position is available immediately.
We also offer places for children aged 4 months and over in our daycare center within walking distance to the institute.
Applications from candidates with international experience are very welcome. The working language within the group is English.
The Max Planck Society strives for gender equality and diversity. We are also committed to increasing the number of individuals with disabilities in our workforce. Therefore, applicants of all backgrounds and identities are welcome.
Your application
The position is available immediately for three years with extension possible. Applications will be evaluated upon receipt until the position is filled.
Please apply by email to bonnie.murphy@biophys.mpg.de with a short letter of motivation explaining your interest in and fit to the position, a CV including contact information for at least one referee and transcript of records.
Please apply by email to bonnie.murphy@biophys.mpg.de with a short letter of motivation explaining your interest in and fit to the position, a CV including contact information for at least one referee and transcript of records.
